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Arachidonic acid- (AA-) containing phosphatidylethanolamine (PE) and adrenic acid- (AdA-) containing PE were previously identified as the primary substrates for lipid peroxidation (Kagan et al., 2020), but mounting evidence raises doubts about this mechanism since a range of polyunsaturated fatty acids (PUFAs) may be implicated in ferroptosis (Zheng and Conrad, 2020)

No, lower back pain is not listed as a common or recognized side effect in FDA prescribing information for semaglutide (Ozempic, Wegovy, Rybelsus)

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For functional enrichment analysis, enriched gene sets were determined by applying the same workflow used for RNA, using the R package gprofiler2 (v.0.2.0)