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The optimal timing strategy varies accordingly
However, efficacy is constrained by strain specificity, dosage thresholds, and host genotype, with risks of microbiota resistance or immune hyperactivation in some patients
A retrospective population-based cohort study demonstrated a longitudinal relationship over 2 years between glycated hemoglobin (HbA1c) levels and increased fracture risk among individuals with T2DM
In trials (DURATION program), once-weekly exenatide 2 mg showed slightly more A1c reduction (~1.5% drop from baseline 8.3%) than Byetta BID (~1.0% drop) with fewer GI side effects after initial weeks ( [6] )
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