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N-acetyl cysteine overdose induced acute toxicity and hepatic microvesicular steatosis by disrupting GSH and interfering lipid metabolisms in normal mice
Sustained, significant weight loss
Maximum benefit: By month 12, most patients have achieved the bulk of their metabolic improvement
Additionally, conflicting findings suggest that prolonged metformin treatment may exacerbate AD pathology in genetically susceptible models, increasing -amyloid accumulation, tau phosphorylation, and synaptic dysfunction 92
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