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Gamma-glutamyltranspeptidase expression regulates the growth-inhibitory activity of the anti-tumor prodrug gamma-L-glutaminyl-4-hydroxy-3-iodobenzene
Emerging nanotechnology, referred as third-generation nanomedicines, offers a promising strategy to protect the stability of these compounds with higher clinical effectiveness at lower doses by enabling precise delivery to subcellular organelles like mitochondria, nucleus, endoplasmic reticulum, lysosomes, and Golgi apparatus, within tumor cells [78, 80, 256]
Laboratory protocols demonstrate that under optimal dosing conditions, the peptide eliminates senescent cells while destroying an undetectable number of healthy cells, representing exceptional selectivity compared to earlier senolytic approaches
In these models, endothelial cells and astrocytes are cultured on the inner and outer surface of the porous hollow fibers (He et al., 2014)
