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GLP-1RAs ameliorate ROS-induced or hyperglycemia-induced apoptosis through modulating IL-6 production and ER stress-induced by hyperhomocysteinemia, via stromal cell-derived factor (SDF)-1/C-X-C motif receptor 7 (CXCR7) -AMPK/p38-MAPK axis [113-115]
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Some clock genes are reported to directly bind the SOD1 promoter, enhancing nocturnal antioxidant defense, or regulate NADPH-generating enzymes to maintain rhythmic reducing power [139]
These models include those of neonatal hippocampal lesion, expression of mutant DISC1 protein and genetic deletion of the key GSH-synthesizing enzyme
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