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Peripheral infusion of GLP-1 decreases food consumption and increases satiety in both normal and obese individuals, presumably by interaction with sensory neurones in the gastrointestinal tract or hepatoportal region (Trapp and Brierley 2022)
Switching to Extended-Release If gastrointestinal side effects are problematic with the immediate-release form, your doctor may switch you to metformin extended-release (ER)
Abdel-Haq M, Ojha SK, Hamoudi W, Kumar A, Tripathi MK, Khaliulin I, et al
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