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In the REDEFINE 1 phase 3 trial, cagrilintide 2.4 mg monotherapy produced an average body weight reduction of 11.8% over 68 weeks
This can lead to tiredness and other health problems
Unlike natural IGF-1 (70 amino acids), IGF-1 LR3 has 83 amino acids : arginine instead of glutamic acid at position 3 (hence R3") and an additional, 13-amino-acid extension at the N-terminus (Long")
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