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Defining the appropriate dosage of MSC-Exos for therapeutic efficacy remains a key challenge, as standardized dosing regimens are yet to be established

Subramani J, Kundumani-Sridharan V, Das KC

Because mesenchymal stem cells (MSCs) have been shown to produce many specific anti-inflammatory effects in neural tissue, "these findings have led to increased interest in MSCs as a potential cell source candidate owing to their immunomodulatory effect [and] MSCs have demonstrated the capability to differentiate into astrocyte-like cells that secrete neurotrophic factors and ameliorate the motor deficits in a rodent model of PD." (4a) (4b)