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Searching for a concrete proof of the advantages of in vivo selenium therapy is problematic, since various studies with a range of dosages have resulted in conflicting results

(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]

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