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Ozempic and Rybelsus are approved for type 2 diabetes, and Wegovy is primarily indicated for weight management in obese and overweight patients, when used along with healthy lifestyle modifications and caloric restrictions

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Although environmental factors such as diet, lifestyle, medication exposure, and metabolic status are major determinants of the gut microbiota, host genetic variation can influence intestinal physiology, immune regulation, bile acid metabolism, epithelial barrier integrity, lipid handling, and inflammatory responses, thereby shaping the ecological conditions in which microbial communities develop (Wu et al., 2023, 2021