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Needle gauge matters too: a finer needle (commonly 29-31 gauge for insulin syringes) reduces the mechanical stress placed on the solution as it passes through the needle bore compared to a larger-bore needle, and produces a smaller, cleaner puncture through the vial's rubber stopper, reducing the risk of coring small rubber fragments breaking off into the solution
Research background
May 24, 1993
[7] [9] As with all parenteral medications, administration should be avoided in the presence of local or systemic infection at the injection site
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