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How Each Compound Works in the Body Retatrutide activates GLP-1, GIP, and glucagon receptors to reduce appetite, increase energy expenditure, and improve insulin secretion

5-Amino-1MQ inhibits the enzyme NNMT (nicotinamide N-methyltransferase), which is involved in NAD+ metabolism within fat cells

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)