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Final percent BMI reduction was 5.1% for GLP-1RA and 0.59% for metformin, with corresponding z-score decreases of 0.02 and 0.01, respectively

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CYP3A4 inhibitors (e.g., itraconazole, ritonavir, cobicistat): These can inhibit the metabolism of corticosteroids, potentially increasing steroid levels and the risk of side effects

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Compared to the inactive GCGR, the extracellular tip of TM7 in peptide 20-bound GCGR moved outward by 5.1 (measured by C atom of L377 7.34b ) and the -helical structure of the extracellular half of TM6 was partially unwounded

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