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Diabetes Care (2016) 39(9):157986

3 The most common were: Nausea (46.6% on the pill vs 18.6% on placebo) Vomiting (30.9% vs 5.9%) Diarrhoea Constipation Stopping the medication due to side effects was 7% with oral semaglutide and 6% with placebo, which is unusually close for a GLP-1 trial, as the placebo group typically has fewer side effects

Therefore, treatment capable of reducing synovial inflammation and slowing down cartilage destruction should have the essential characteristics of disease-modifying OA drugs (DMOADs)

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