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The lack of expression of several PRRs in human FAPs likely explains why direct incubation with CpG oligodeoxynucleotide (TLR9 ligand) or Gardiquimod (TLR7 and TLR8 ligand) did not stimulate human FAP mineralization

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The activation of these pathways can also induce the production of growth factors, such as TGF-beta and IGF-1, which promote fibroblast proliferation and collagen synthesis, enhancing the strength and repair capacity of the ligament