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proceedings of the national academy of sciences

Safety considerations and patient selection Choosing the right candidate means evaluating your overall health, medications, functional ability, and lab results and monitoring closely once you start, since people over 65 face higher risks of side effects and interactions

And in blood vessels that are already less flexible or have cholesterol plaques, reintroducing estrogen in the form of hormone replacement therapy can increase the force and speed of blood flow with each heartbeat, sometimes causing a plaque in a vessel to break off and raising the risk of serious problems like heart attack, stroke, or blood clots, says Chervenak