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This mechanism helps explain why burping and other upper gastrointestinal symptoms are among the most frequently reported adverse effects during tirzepatide therapy

Notch signalling drives synovial fibroblast identity and arthritis pathology

This is especially concerning with products advertised as retatrutide, GLP-3, research peptides, or compounded versions of popular medications

Whats more, studies on animals have shown GLP-1s can lead to miscarriage or birth defects, which is why most manufacturers recommend stopping taking the drugs during pregnancy, or at least two months before you plan to fall pregnant if at all possible