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The cultural shift toward recognizing and treating perimenopausedriven by patient advocacy, social media, and high-profile coveragemeans women are presenting earlier, often in their late 30s and early 40s, with irregular cycles, vasomotor symptoms, sleep disruption, and mood changes

For ED medications, that means no history of cardiovascular dysfunction (e.g., angina, arrhythmia, low blood pressure) and no pertinent allergies

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In older adults, lifestyle modifications remain a significant challenge [11, 20], and the increasing burden of NCDs further underscores the strategic role of pharmacotherapy as part of a comprehensive strategy of the obesity management