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In contrast, the beneficial effects of SGLT2 inhibitors on albuminuria and eGFR decline in DKD were demonstrated by EMPA-REG OUTCOME (Wanner et al., 2016), CANagliflozin cardioVascular Assessment Study (CANVAS) ( Statements Author contributions DK and YT wrote and revised the manuscript

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Taken together, current evidence indicates that while a definitive causal relationship between GLP-1 RA therapy and severe motility disorders has not been established, clinicians should remain vigilant for GI symptoms suggestive of delayed gastric emptying or obstruction

Pollari E, Goldsteins G, Bart G, Koistinaho J, Giniatullin R