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However, due to its large molecular weight and hydrophobicity (poor water solubility), the oral administration of CoQ10 exhibits restricted systemic uptake

Because IGF-1 LR3 is a folded protein of roughly 9.1 kDa carrying three disulfide bridges rather than a short synthetic peptide, agitation is the main practical hazard: shear and air-liquid interface exposure drive aggregation, so swirl only and never shake

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