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it is a fully synthetic medication manufactured using recombinant DNA technology in yeast cells

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Stimulant-based supplements: Products containing high-dose caffeine, bitter orange (synephrine), or ephedrine-like compounds may worsen anxiety, disrupt sleep, and increase cardiovascular risk concerns that are particularly relevant in people already managing chronic pain and fatigue

For some people, berberine can be dangerous Both medical experts Insider spoke with for this story agreed that pure berberine is a relatively safe, well-tolerated compound