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Key points: Orforglipron, a once-daily non-peptide oral GLP-1 pill, has shown weight loss results similar to peptide-based GLP-1 medications in early clinical trial data

Efficacy in Blood Sugar Control Semaglutide: Highly effective in managing blood sugar levels in type 2 diabetes patients, lowering A1C by an average of 1.8%

She, Schmidt and Yammine believe that semaglutide's ability to disrupt this out-of-control reward system may be responsible for reduced cravings, for food and nicotine alike (and research suggests it may work similarly for other substances too)

In addition, long- and short-term creatine supplementation has been shown to increase muscle mass (and potentially reduce fat mass) in active individuals [7]