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Left unchecked, free radicals damage cells, destabilize the immune system, and contribute to the development of serious health problems

Rosmarinic acid (25 and 50 mg/kg, p.o., 4 weeks) effectively relieved oxidative stress (e.g., lipid peroxidation, nitrite levels, and DNA fragmentation), improved mitochondrial function, prevented the loss of ATP levels, reduced spinal cord inflammation (e.g., TNF- and IL-6), and, meanwhile, maintained the levels of phosphorylated adenosine 5-monophosphate-activated protein kinase (AMPK) in the sciatic nerves, thus, significantly reversing the mechanical allodynia and cold hyperalgesia in rats of PIPN (Areti et al., 2018)

Compounded medications are not FDA-approved but are prepared under strict regulatory standards with a prescription

Vakov J, et al