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Under hypoxia, cells induce the release of pro-inflammatory mediators through a variety of pathways, including but not limited to tumor necrosis factor- (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6), and vasoactive mediators such as histamine and bradykinin ( Tissue Edema: Examples include high altitude cerebral edema (HACE) and high altitude pulmonary edema (HAPE), which are severe complications of high altitude illnesses

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Hydroperoxide metabolism in mammalian organs

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