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Aside from hyperhomocysteinemia, C677T or A1298C MTHFR (the two genes most studied) mutations are associated with an increased risk of other conditions including cardiovascular and thromboembolic diseases such as strokes, blood clots, and heart attacks, ADHD in children, pregnancies with neural tube defects, depression, anxiety, diabetic neuropathy, glaucoma migraines, schizophrenia, and colorectal polyps

Source: Deanfield, et al The Lancet, October 22, 2025

The researchers were able to measure GLP-1 in synovial fluid - the liquid within joint cavities - of patients with inflammatory rheumatic diseases

You do not need to worry about oral B12 absorption being compromised by the same medication you are taking