What This Looks Like in Practice If you're on Ozempic, Wegovy, or any GLP-1 medication, here's what an effective training approach includes: Frequency: 23 strength sessions per week minimum Focus: Compound movements squats, deadlifts, pressing, pulling that recruit the most muscle Protein: Aim for 1.62.2g per kg of bodyweight daily to offset appetite suppression Intensity: Keep training challenging appetite suppression can reduce perceived effort, but the muscle stimulus still needs to be there Recovery: Prioritise sleep and manage stress, both of which affect muscle retention Training on GLP-1 in Singapore: What to Expect Lower appetite can affect energy levels, especially in the first 48 weeks of GLP-1 use

Contraindications and precautions include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, history of pancreatitis (requires careful consideration), severe gastrointestinal disease, diabetic retinopathy (requires caution), and pregnancy or planned pregnancy
Retatrutide does not cause fatigue through a single mechanism
doi: 10.3390/molecules27020452 175 ChangMLYangZYangSS