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A meta-analysis of over 80,000 patients reported 16: 16% reduction in kidney failure risk 18% reduction in worsening kidney function These benefits are thought to be largely driven by improvements in: Blood sugar control Blood pressure Body weight and inflammation Fertility and Reproductive Function GLP-1 therapies have also been linked to improvements in fertility outcomes, particularly in individuals with obesity or insulin resistance

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In addition, brain insulin resistance affects tau metabolism and promotes the hyperphosphorylation of tau proteins, tau protein aggregation, the formation of paired helical filaments, and the further formation of NFTs (Mohandas et al., 2009)