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Front Endocrinol (Lausanne) (2018) 9:10
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide that acts as a potent signaling molecule for extracellular matrix remodeling
That multi-target design is why it has drawn attention in metabolic medicine: engaging three pathways rather than one produced larger average weight reduction in early testing than single-pathway incretin agents have shown in their own trials
In gene expression profiling, GHK-Cu treatment of human fibroblasts upregulated superoxide dismutase (SOD1, SOD2, SOD3) and glutathione-related genes while suppressing NF-kB-driven inflammatory signaling [3]
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