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Avoid high-fat and greasy foods during the first two weeks after each dose increase, as fat takes longest to digest and compounds the slowed gastric emptying effect
any infusion should have immediate access to emergency care
Initially, they had planned to continue the study for a further year, but because of the lack of positive results, they cancelled the extension
Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)
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