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From a contemporary clinical perspective, these findings also align with the recently proposed cardiovascularkidneymetabolic (CKM) syndrome framework, which emphasizes the interconnected pathophysiology of metabolic dysfunction, CV disease, and kidney disease across a continuum of risk
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Discussion Since reports to the European Medicines Agency of depression and suicidality in patients taking GLP-1RAs, large studies have demonstrated conflicting results regarding the association of these drugs with mood disturbance and suicidality
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