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15 Although many research studies and clinical laboratories define vitamin B 12 deficiency at a level of less than 150 pg per mL (110.67 pmol per L), or in some cases 200 pg per mL, patients with values above these levels may be symptomatic and benefit from treatment

[3] For example, someone with borderline thiamine and B deficiency might feel less brain fog, improved mood, and better stamina as those vitamins are replenished

PMID 12788900

The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks