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Semaglutide is also the first (and so far only) GLP-1 receptor agonist shown to decrease the risk of heart attacks and strokes among people who dont have diabetes, so thats a game changer in the landscape of obesity medicine, Pedersen says

5 , 178ra40 (2013)

Individuals who used GLP-1RAs for 0.5, 1, and 1.5 years had IRRs close to 1.0, with no significant decrease in MACE risk at three years, although these estimates varied across specific treatment strategies defined by prior duration and subsequent exposure patterns

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