Potent therapeutic GLS inhibitors, such as bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) and its analogs such as CB-839, are being actively investigated in GLS-targeting studies [38, 54,55,56,57,58]
Together, this cross-species comparison reveals conserved remodeling in MS and toxin demyelination models, including upregulation of core DAM signature genes and suppression of homeostatic microglial identity, though LPC notably reflects a shift toward lysosomal myelin debris clearance, whereas CPZ reflects chronic stress and metabolic adaptation
(PubMed) van Gelder BM, Tijhuis M, Kalmijn S, Kromhout D
For the scVI model, the batch key was set to the sample_id (representing each individual sample), and RNA count and percent mitochondrial count were given as continuous covariates