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Treatments began once tumors reached a size of 5 5 mm (approximately 65 mm 3 ), with termination of the experiment when all isotype-matched controls had reached the end-point
If insufficient, osmotic laxatives such as polyethylene glycol are generally safe and effective as first-line agents per AGA-ACG guidelines
doi: 10.1016/S2213-2600(19)30198-5, 2
The first set is dominated by central nervous-system signaling (hypothalamus, NTS, area postrema)
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