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Additionally, ASPS was found to increase the metabolite GGC, which inhibits ASC nucleation, blocks NLRP3 inflammasome activation, and consequently reduces caspase-1 and IL-1 levels (17)
10.1016/j.tcb.2011.03.007 61 Mario G., Niso-Santano M., Baehrecke E
Mitochondrial dysfunction in obesity
This paired format is especially useful in controlled research settings where both GHRH and GHSR signaling mechanisms are part of the same study design
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