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Glossary 3-HK 3-hydroxykynurenine 5-HT Serotonin BAs Bile acids BBB Blood-Brain Barrier BDI Beck Depression Inventory BDNF Brain-Derived Neurotrophic Factor CD Crohns Disease CNS Central Nervous System CRP C-Reactive Protein DASS Depression Anxiety Stress Scales FMT Fecal Microbiota Transplantation GABA Gamma-aminobutyric Acid GALT Gut-Associated Lymphoid Tissue GHQ General Health Questionnaire GRK2 G protein-coupled receptor kinase 2 HADS Hospital Anxiety and Depression Scale HAM-D Hamilton Depression Rating Scale HPA Hypothalamic-Pituitary-Adrenal Axis HR Hazard Ratio IBD Inflammatory Bowel Disease IBD-AID Anti-Inflammatory Diet for IBD IBS Irritable Bowel Syndrome IDO Indoleamine 2,3-dioxygenase IFN- Interferon-gamma IL Interleukin KP Kynurenine Pathway KYN Kynurenine KYNA Kynurenic acid LPS Lipopolysaccharide MAMPs Microbe-Associated Molecular Patterns MDD Major Depressive Disorder MGBA Microbiota-Gut-Brain Axis NF-B Nuclear Factor kappa B NMDA N-methyl-D-aspartate NTS Nucleus of the Solitary Tract PAEs Paradoxical psychiatric adverse events PAMPs Pathogen-Associated Molecular Patterns PHQ-9 Patient Health Questionnaire-9 QUIN Quinolinic Acid SCFAs Short-Chain Fatty Acids SSRI Selective serotonin reuptake inhibitor TDO tryptophan 2,3-dioxygenase Th T helper cells TLR4 Toll-like Receptor 4 TNF- Tumor Necrosis Factor-alpha Treg Regulatory T cells TRP Tryptophan UC Ulcerative Colitis References 1 AbdelbadieeS.YoonG.PearmanK.KumarA.HarveyP

62 In this context, our results support a model in which Trim37 -deficient PGCs exit the germline program and enter an aberrant somatic-like state marked by partial and heterogeneous activation of multiple somatic gene programs, rather than bona fide lineage-restricted transdifferentiation

The Role of Testosterone Therapy in Men's Health