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Treat patients with noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), previously called nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (stages F2 to F3)
The three mechanisms are: (1) slowed gastric emptying paired with a bile acid surge, (2) direct GIP/GLP-1 receptor activation in the intestine itself, and (3) a rebalancing gut microbiome
Osilyhizidine (OSR), from Sophora alopecuroides, has anti-inflammatory/antioxidant properties, but its OA-specific effects and mechanisms were unclear
There was concern about having to stop the medication that was finally helping reach health goals
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