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The GSTP1 rs4147581 is in linkage disequilibrium with rs1695 (D = 0.99, R 2 = 0.44 in Admixed American populations, including Colombians), a common nonsynonymous SNP that changes the 105th amino acid from isoleucine to valine, altering the substrate binding site of GSTP1 38
[53 ] In a phase I human trial of cisplatin with 13-cis-retinoic acid (cRA), the two agents were noted to have strong synergism against head and neck squamous cell carcinoma
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