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10.1186/s43159-022-00189-w 34
Contrave is a prescription combination of naltrexone and bupropion that targets two areas of the brain involved in appetite and cravings: Bupropion activates neurons in the hypothalamus that naturally suppress appetite -Naltrexone blocks the brains counter-signal that would normally mute that appetite suppression Together, they keep the appetite-reducing effect switched on longer than either drug achieves alone The result is a reduction in food cravings, less reward-seeking behavior around eating, and for many patients, a quieter mental relationship with food without relying on stimulants or gut hormone changes.Heres the key mechanism: the hypothalamus is the part of your brain that regulates appetite and energy balance
In those patients, addressing the underlying metabolic dysfunction first, through dietary intervention, GLP-1 therapy if indicated, or NAD+ support for cellular energy metabolism, is the clinical priority
The World Health Organization's guidance on travelling with medicines recommends carrying a translated prescription or a physician's letter in the local language of the destination country [4]
