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Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats

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The research on this remains mostly anecdotal, but some clinical evidence is emerging

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That does not sound like much until you consider that losing 10 pounds of lean mass, which is entirely possible on GLP-1 medications without strength training, could reduce your daily calorie burn by 60-100 calories permanently

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