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Collectively, these findings highlight the critical role of SLC25A39-mediated mitochondrial glutathione import in preventing a localized, intra-mitochondrial oxidative crisis that directly initiates apoptotic cell death

Mitochondrial SIRT3 as a protective factor against cyclosporine A-induced nephrotoxicity

The PGC-1-Nrf1 axis also stimulates the transcription of mitochondrial gene-encoded factors, including mitochondrial transcription factor B1 (TFB1M), TFB2M, and mitochondrial transcription factor A (TFAM), which mediate mtDNA replication and transcription [23]