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This churn drives up marketing and administrative costs for payers and employers, and disincentives payer investment in prevention, diagnosis, and management of chronic illnesses (such as obesity and the conditions associated with it)

Moreover, Ex-4 induces autophagy and attenuates ovarian cancer cell viability by upregulating the expression of autophagic markers beclin-1 and microtubule-associated proteins light chain 3I/II (LC3I/II), while simultaneously downregulating the expression of p62 (a linker protein for LC3II) [68]

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