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further demonstrated that TMAO inhibits TGF- RI ubiquitination, reducing proteasomal degradation, prolonging its half-life, and sustaining Smad2 phosphorylation/fibrotic gene transcription (e.g., -SMA, collagen I) (Yang et al., 2019)
By briefly blocking the OGF receptor, LDN appears to upregulate this entire pathway, supporting immune surveillance and, in some cases, limiting progression of inflammatory or immune-mediated concerns
Additionally, many patients experience weight regain when they stop the injections, as the drugs blunt the bodys natural weight-regulating systems rather than support them
Useful as that might be for helping people with addiction, there has been some concern about the unwanted consequences of these changes to the brain
