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As a natural allosteric activator of PKM2, the final enzyme in glycolysis, serine also modulates glycolytic flux [19]
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When the rats were 7 weeks old, they were fasted overnight (1418 h) and divided into four groups of six animals each for the in vivo bioavailability study
Many of the studies are conducted following a randomized, double-blind and placebo-controlled (RDP) methodology to assess the efficacy of the extract in comparison to potential placebo effects
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