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The HQ hydroxyl group is oriented towards ZnA, and its benzyl ring is stabilized through hydrophobic interactions with His208, similar to tyrosine substrates (Fig
Much of this evidence derives from animal models precisely because these integrated tissue-level responses cannot yet be recapitulated in vitro or in silico
Here is how that plays out, step by step
The July 23-24 PCAC meeting will advise, but FDA makes the final call later
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