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Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-B (nuclear factor B) signals

Relaying of this signal to other parts of the body, such as the liver, pancreas or brain is then required in turn to engage appropriate responses, such as getting the body ready to digest the food, prepare insulin release and to make us feel full

[5] It has been hypothesized to act through GH-mediated pathways on the osteoblasts (bone-forming cells), possibly leading to increased proliferation, development, and differentiation of the osteoblasts

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