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The FDA label states that providers should consider discontinuing treatment if patients do not achieve at least 5% weight loss after 12 weeks at the maintenance dose, as continued use is unlikely to provide meaningful clinical benefit

Healthcare providers carefully tailor tirzepatide doses based on individual patient needs, medical history, and response to treatment

The article recommends ophthalmology clearance before starting GLP-1 therapy for anyone with known diabetic eye disease, plus periodic follow-up afterward