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Although endogenous antioxidant systems normally maintain redox balance, chronic hyperglycemia disrupts this equilibrium and results in sustained ROS overload
At the same time, it can accelerate the metabolism of fat, improve the energy utilization efficiency of the body, enable athletes to better utilize fat as an energy source during exercise, reduce dependence on glycogen, and delay the occurrence of fatigue
Frontiers in Pharmacology , 12, 627533
Indeed, recent studies have shown that HIF-2 can be targeted by selective inhibitors and have indicated that these molecules effectively suppress cancer cell growth and tumor angiogenesis characteristics in ccRCC 79,80,81,82
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