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Both alcohol and isoniazid induce CYP2E1 and affect APAP-induced ALI by increasing NAPQI, the hepatotoxic metabolite of APAP, indicating that CYP2E1 may be the major P450 contributing to conversion of APAP to NAPQI (Zand et al., 1993
IGF-1R has been implicated in several different types of cancer include breast, prostate, and lung cancer
143 Togha, M., Razeghi Jahromi, S., Ghorbani, Z., Martami, F
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