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A retrospective cohort study published in JAMA Oncology (n=86,632) found that adults with obesity taking GLP-1s had significantly reduced risk of overall cancer, particularly endometrial and ovarian cancers and meningioma, compared to non-GLP-1 users
How semaglutide works Semaglutide is a GLP-1 receptor agonist that mimics the natural GLP-1 hormone your body produces in response to eating
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But the AAOS data is from five years of real-world use, not a short-term trial, and the divergence may simply reflect that shorter-term effects on bone markers dont capture what happens over years of use
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